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Apr 18 2022

Blood Flow Dynamics Near the Vessel Wall: From Flow Physics to Scientific Machine Learning

MIE Faculty Candidate Seminar

April 18, 2022

11:00 AM - 12:00 AM


1043 ERF and on Zoom at


842 W. Taylor St., CHICAGO, IL 60607

Presenter: Amirhossein Arzani, PhD, Northern Arizona University
Location: 1043 ERF or on Zoom
Meeting ID: 885 4281 5005
Passcode: nRcrHqF7

Abstract: Major forms of cardiovascular disease localize at the vessel wall. Fluid mechanics of blood flow near the wall and derived parameters such as wall shear stress (WSS) are known to regulate vascular disease growth.

In the first part of the talk, I will present the complex flow physics near the vessel wall of diseased arteries. I will introduce the concept of WSS topology (manifolds) and demonstrate the complex and hidden topological patterns in WSS vector field that are usually ignored. I will discuss the connection between these WSS patterns and coherent structures away from the wall and demonstrate the role of WSS manifolds in determining near-wall mass transport patterns. The potential extension of this theory to convective heat transfer will also be discussed.

In the second part of the talk, I will present different scientific machine learning approaches to overcome limitations in the experimental and computational quantification of WSS. I will demonstrate how we can leverage hidden sparsity in data and use reduced-order modeling to improve blood flow data fidelity. Finally, I will present a physics-informed neural network (PINN) framework for obtaining WSS from sparse velocity measurements away from the wall and without full knowledge of the boundary conditions. I will show how PINN could integrate imperfect blood flow data (sparse and outside the region of interest) with incomplete knowledge of the physics (Navier-Stokes equations without full boundary conditions) to obtain accurate results.

Speaker Bio: Dr. Amirhossein (Amir) Arzani is a tenure-track assistant professor of mechanical engineering at Northern Arizona University. He obtained his BSc, MSc, and PhD degrees in mechanical engineering from Isfahan University of Technology, Illinois Institute of Technology, and UC Berkeley, respectively. He is the director of the Cardiovascular Biomechanics Lab at NAU ( and a recipient of the NSF CAREER Award. His research utilizes various computational mechanics and data-driven techniques to study biological flows and soft tissue mechanics.


Dr. Hamed Hatami-Marbini

Date posted

Apr 4, 2022

Date updated

Apr 4, 2022